Gene information
Official symbol IL17A
Official full name interleukin 17A
Gene type protein-coding gene
Chromosome6p12.2
Alias symbolIL-17A; IL-17
Previous symbolCTLA8; IL17
Gene familyInterleukins
Resources
Entrez Gene 3605
HGNC HGNC:5981
Ensembl ENSG00000112115
Vega OTTHUMG00000014840
UCSC uc003pak.1
GO terms: 71 records
GO Description Category LogP Number of genes Detail
GO:0001775 cell activation GO Biological Processes -43.3738118 71 More
GO:0001819 positive regulation of cytokine production GO Biological Processes -44.1872667 64 More
GO:0001894 tissue homeostasis GO Biological Processes -10.3152206 20 More
GO:0002250 adaptive immune response GO Biological Processes -8.22919489 29 More
GO:0002697 regulation of immune effector process GO Biological Processes -33.2683521 48 More
GO:0002699 positive regulation of immune effector process GO Biological Processes -18.3926498 29 More
GO:0002700 regulation of production of molecular mediator of immune response GO Biological Processes -19.7615296 26 More
GO:0002702 positive regulation of production of molecular mediator of immune response GO Biological Processes -12.4206918 17 More
GO:0002761 regulation of myeloid leukocyte differentiation GO Biological Processes -12.4818724 17 More
GO:0002763 positive regulation of myeloid leukocyte differentiation GO Biological Processes -8.56410954 10 More
GO:0002831 regulation of response to biotic stimulus GO Biological Processes -10.931136 25 More
GO:0002833 positive regulation of response to biotic stimulus GO Biological Processes -5.95822718 13 More
GO:0002920 regulation of humoral immune response GO Biological Processes -5.73581155 7 More
GO:0002922 positive regulation of humoral immune response GO Biological Processes -6.27426612 6 More
GO:0005125 cytokine activity GO Molecular Functions -54.7097150 57 More
GO:0006954 inflammatory response GO Biological Processes -86.5569367 100 More
GO:0007219 Notch signaling pathway GO Biological Processes -2.15030944 11 More
GO:0007586 digestion GO Biological Processes -7.00342423 19 More
GO:0009617 response to bacterium GO Biological Processes -52.1760880 83 More
GO:0009620 response to fungus GO Biological Processes -9.57465113 11 More
GO:0010669 epithelial structure maintenance GO Biological Processes -3.21919661 4 More
GO:0019221 cytokine-mediated signaling pathway GO Biological Processes -27.5840932 43 More
GO:0022600 digestive system process GO Biological Processes -8.16734280 17 More
GO:0030277 maintenance of gastrointestinal epithelium GO Biological Processes -3.92689699 4 More
GO:0030545 signaling receptor regulator activity GO Molecular Functions -87.4728446 102 More
GO:0030546 signaling receptor activator activity GO Molecular Functions -90.4065983 101 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0031349 positive regulation of defense response GO Biological Processes -32.1301903 71 More
GO:0032103 positive regulation of response to external stimulus GO Biological Processes -58.7273809 118 More
GO:0032642 regulation of chemokine production GO Biological Processes -25.2850711 37 More
GO:0032651 regulation of interleukin-1 beta production GO Biological Processes -19.7300517 34 More
GO:0032652 regulation of interleukin-1 production GO Biological Processes -24.2088254 41 More
GO:0032655 regulation of interleukin-12 production GO Biological Processes -15.9447313 16 More
GO:0032667 regulation of interleukin-23 production GO Biological Processes -3.75458174 3 More
GO:0032675 regulation of interleukin-6 production GO Biological Processes -28.2553997 51 More
GO:0032680 regulation of tumor necrosis factor production GO Biological Processes -32.0729913 56 More
GO:0032722 positive regulation of chemokine production GO Biological Processes -22.4503100 21 More
GO:0032731 positive regulation of interleukin-1 beta production GO Biological Processes -11.8061175 13 More
GO:0032732 positive regulation of interleukin-1 production GO Biological Processes -14.7376831 16 More
GO:0032735 positive regulation of interleukin-12 production GO Biological Processes -12.7826256 12 More
GO:0032755 positive regulation of interleukin-6 production GO Biological Processes -18.6559032 31 More
GO:0032760 positive regulation of tumor necrosis factor production GO Biological Processes -21.1788990 23 More
GO:0042742 defense response to bacterium GO Biological Processes -25.9215771 41 More
GO:0042803 protein homodimerization activity GO Molecular Functions -14.2815375 77 More
GO:0044089 positive regulation of cellular component biogenesis GO Biological Processes -10.7794496 56 More
GO:0045637 regulation of myeloid cell differentiation GO Biological Processes -9.39364926 18 More
GO:0045639 positive regulation of myeloid cell differentiation GO Biological Processes -7.07849207 11 More
GO:0045670 regulation of osteoclast differentiation GO Biological Processes -10.2566667 12 More
GO:0045672 positive regulation of osteoclast differentiation GO Biological Processes -7.61299657 7 More
GO:0046982 protein heterodimerization activity GO Molecular Functions -2.81006698 12 More
GO:0048018 receptor ligand activity GO Molecular Functions -91.0736151 101 More
GO:0048871 multicellular organismal homeostasis GO Biological Processes -14.5562171 53 More
GO:0050778 positive regulation of immune response GO Biological Processes -17.2528761 40 More
GO:0050829 defense response to Gram-negative bacterium GO Biological Processes -15.0142277 17 More
GO:0050830 defense response to Gram-positive bacterium GO Biological Processes -13.1972375 17 More
GO:0050832 defense response to fungus GO Biological Processes -7.96091962 9 More
GO:0050900 leukocyte migration GO Biological Processes -39.9164759 46 More
GO:0060249 anatomical structure homeostasis GO Biological Processes -12.3640817 24 More
GO:0070555 response to interleukin-1 GO Biological Processes -18.9736890 36 More
GO:0071345 cellular response to cytokine stimulus GO Biological Processes -39.647808 70 More
GO:0071347 cellular response to interleukin-1 GO Biological Processes -16.1002741 19 More
GO:0097529 myeloid leukocyte migration GO Biological Processes -25.8454617 28 More
GO:0097530 granulocyte migration GO Biological Processes -19.1764933 21 More
GO:1901888 regulation of cell junction assembly GO Biological Processes -8.71146171 30 More
GO:1901890 positive regulation of cell junction assembly GO Biological Processes -5.75086352 17 More
GO:1902105 regulation of leukocyte differentiation GO Biological Processes -18.8286876 32 More
GO:1902107 positive regulation of leukocyte differentiation GO Biological Processes -14.6775052 22 More
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production GO Biological Processes -32.3948799 57 More
GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production GO Biological Processes -20.7768498 23 More
GO:1903706 regulation of hemopoiesis GO Biological Processes -16.2759166 33 More
GO:1903708 positive regulation of hemopoiesis GO Biological Processes -14.6775052 22 More
KEGG pathways: 5 records
KEGG Description Category LogP Number of genes Detail
hsa04060 Cytokine-cytokine receptor interaction KEGG Pathway -61.0014447 66 More
hsa04657 IL-17 signaling pathway KEGG Pathway -16.8039621 19 More
hsa04659 Th17 cell differentiation KEGG Pathway -9.80516906 14 More
hsa04936 Alcoholic liver disease KEGG Pathway -13.3477535 19 More
hsa05323 Rheumatoid arthritis KEGG Pathway -22.3868189 23 More
Drug-Gene interaction
view
Related drugs: 16 records
Drug name Interaction type Source PMID View
abbv-257 TTD view
bimekizumab TTD view
brodalumab TTD view
cjm-112 TTD view
erythromycin NCI 17061983 view
gentamicin NCI 18802100 view
ixekizumab inhibitorantibody ChemblInteractionsTTD view
m-1095 TTD view
mannitol NCI 18310510 view
remtolumab TTD view
secukinumab antagonistinhibitor ChemblInteractions 25354738 view
simvastatin NCI 18203812 view
sirolimus NCI 17061983 view
tetracycline NCI 17785852 view
vidofludimus TdgClinicalTrial view
vunakizumab TTD view
Related studies: 3 records
Molecular factor Omics type Application Objective MI type Reference
interleukin-17A proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Bochaton T et al.PLoS One. 2017
interleukin-17A proteomics monocyte count[other] acute ST elevation myocardial infarction Garza-Reyes MG et al. J Immunol Res. 2020
interleukin-17A proteomics cardiovascular adverse events[prognosis (bad)] acute myocardial infarction Simon T et al. Eur Heart J. 2013
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